This article reports the findings of a scientometric analysis of South Africa’s research performance during the period 2000–2010. A multitude of government incentives were introduced during the period and their effects have appeared in the country’s research outputs. In contrast to earlier investigations, it was found that South Africa’s world share of publications is on the verge of reaching the highest contribution ever. South Africa improved its international ranking by two positions during 2000–2010 and was ranked 33rd in the world during 2010. It is argued that, provided the plan of the Minister of Science and Technology to increase the research and development expenditure in the country materialises, South Africa may be on the verge of a scientific renaissance.